Tubing-Free Microfluidic Microtissue Culture System Featuring Gradual, in vivo-Like Substance Exposure Profiles

In vitro screening methods for compound efficacy and toxicity to date mostly include cell or tissue exposure to preset constant compound concentrations over a defined testing period. Such concentration profiles, however, do not represent realistic in vivo situations after substance uptake. Absorptio...

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Bibliographic Details
Main Authors: Christian Lohasz, Olivier Frey, Flavio Bonanini, Kasper Renggli, Andreas Hierlemann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00072/full