Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease

Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease

Paget's disease of bone (PDB) is an age-related metabolic bone disorder, characterised by focally increased and disorganised bone remodelling initiated by abnormal and hyperactive osteoclasts. The germline P392L mutation of SQSTM1 (encoding p62) is a strong genetic risk factor for PDB in humans...

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Bibliographic Details
Main Authors: Anna Daroszewska, Lorraine Rose, Nadine Sarsam, Gemma Charlesworth, Amanda Prior, Kenneth Rose, Stuart H. Ralston, Robert J. van ‘t Hof
Format: Article
Language:English
Published: The Company of Biologists 2018-09-01
Series:Disease Models & Mechanisms
Subjects:
Paget's disease of bone
Genetic animal models
Ageing
Bone morphometry
Antiresorptives
Zoledronic acid
Online Access:http://dmm.biologists.org/content/11/9/dmm035576

Internet

http://dmm.biologists.org/content/11/9/dmm035576

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