Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease
Paget's disease of bone (PDB) is an age-related metabolic bone disorder, characterised by focally increased and disorganised bone remodelling initiated by abnormal and hyperactive osteoclasts. The germline P392L mutation of SQSTM1 (encoding p62) is a strong genetic risk factor for PDB in humans...
Main Authors: | Anna Daroszewska, Lorraine Rose, Nadine Sarsam, Gemma Charlesworth, Amanda Prior, Kenneth Rose, Stuart H. Ralston, Robert J. van ‘t Hof |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2018-09-01
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Series: | Disease Models & Mechanisms |
Subjects: | |
Online Access: | http://dmm.biologists.org/content/11/9/dmm035576 |
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