The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection

The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection

The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against n...

Full description

Bibliographic Details
Main Authors: Antonella D’Amore, Antonella Gradogna, Fioretta Palombi, Velia Minicozzi, Matteo Ceccarelli, Armando Carpaneto, Antonio Filippini
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
TPC channels
plant vacuole
mammalian endolysosome
flavonoids
coronavirus
SARS-CoV-2
Online Access:https://www.mdpi.com/2073-4409/10/5/1130

Internet

https://www.mdpi.com/2073-4409/10/5/1130

Similar Items