Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxinSummary

Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxinSummary

Background and Aims: Characterization of cell specific transcriptional responses to hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single-cell/nuclei RNA-seq technologies enable the transcriptomes of individual cell (sub)types to be assessed within the context of in vivo m...

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Bibliographic Details
Main Authors: Rance Nault, Kelly A. Fader, Sudin Bhattacharya, Tim R. Zacharewski
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Transcriptomics
TCDD
Hepatotoxicant
Cellular Heterogeneity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20301181

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http://www.sciencedirect.com/science/article/pii/S2352345X20301181

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