Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is uniquely susceptible to rapid ubiquitin-mediated degradation in macrophages, fu...

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Bibliographic Details
Main Authors: Ben F Brian IV, Adrienne S Jolicoeur, Candace R Guerrero, Myra G Nunez, Zoi E Sychev, Siv A Hegre, Pål Sætrom, Nagy Habib, Justin M Drake, Kathryn L Schwertfeger, Tanya S Freedman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
SFKs/Src-family kinases
Cbl E3 ubiquitin ligase
myeloid cell signaling
macrophage
mast cell
LynA
Online Access:https://elifesciences.org/articles/46043

Internet

https://elifesciences.org/articles/46043

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