Dual Deep Sequencing Improves the Accuracy of Low-Frequency Somatic Mutation Detection in Cancer Gene Panel Testing

Dual Deep Sequencing Improves the Accuracy of Low-Frequency Somatic Mutation Detection in Cancer Gene Panel Testing

Cancer gene panel testing requires accurate detection of somatic mosaic mutations, as the test sample consists of a mixture of cancer cells and normal cells; each minor clone in the tumor also has different somatic mutations. Several studies have shown that the different types of software used for v...

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Bibliographic Details
Main Authors: Hiroki Ura, Sumihito Togi, Yo Niida
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
somatic variant detection
clinical sequencing
next generation sequencing
cancer gene panel testing
somatic variant caller
mosaic mutation
Online Access:https://www.mdpi.com/1422-0067/21/10/3530

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https://www.mdpi.com/1422-0067/21/10/3530

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