A unique role for the host ESCRT proteins in replication of Tomato bushy stunt virus.

Plus-stranded RNA viruses replicate in infected cells by assembling viral replicase complexes consisting of viral- and host-coded proteins. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host revealed the involvement of seven ESCRT (endosomal sorting complex...

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Bibliographic Details
Main Authors: Daniel Barajas, Yi Jiang, Peter D Nagy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2791863?pdf=render