Diverse Effects of the NTCP p.Ser267Phe Variant on Disease Progression During Chronic HBV Infection and on HBV preS1 Variability

Diverse Effects of the NTCP p.Ser267Phe Variant on Disease Progression During Chronic HBV Infection and on HBV preS1 Variability

The sodium taurocholate co-transporting polypeptide (NTCP) acts as a cellular receptor for the hepatitis B virus (HBV) infection on host hepatocytes. We aim to investigate how the NTCP p.Ser267Phe variant affects HBV-related disease progression and analyze viral genomic variability under a host gene...

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Bibliographic Details
Main Authors: Fangji Yang, Lina Wu, Wenxiong Xu, Ying Liu, Limin Zhen, Gang Ning, Jie Song, Qian Jiao, Yongyuan Zheng, Tongtong Chen, Chan Xie, Liang Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
sodium taurocholate co-transporting polypeptide (NTCP)
hepatitis
hepatitis B virus (HBV)
preS1 region
single nucleotide polymorphism (SNP)
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00018/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00018/full

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