CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis

CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis

Abstract VEGF-C is essential for lymphangiogenesis during development and tumor progression. VEGFR-3 is the well-known cognate receptor of VEGF-C to regulate lymphatic migration and proliferation, but the receptor of VEGF-C in regulating lymphatic sprouting, the initiating step of lymphangiogenesis,...

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Bibliographic Details
Main Authors: Huiwen Yan, Chunxia Zhang, Zhaoqing Wang, Tao Tu, Hongxia Duan, Yongting Luo, Jing Feng, Feng Liu, Xiyun Yan
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06637-7

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https://doi.org/10.1038/s41598-017-06637-7

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