A flexible and accurate genotype imputation method for the next generation of genome-wide association studies.

Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as controls genotyped on multiple SNP chips and densely typed samples from the 1,000...

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Bibliographic Details
Main Authors: Bryan N Howie, Peter Donnelly, Jonathan Marchini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2689936?pdf=render