In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147.

CD44 and CD147 are associated with cancer metastasis and progression. Our purpose in the study was to investigate the effects of down-regulation of CD44 or CD147 on the metastatic ability of prostate cancer (CaP) cells, their docetaxel (DTX) responsiveness and potential mechanisms involved in vitro...

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Main Authors: Jingli Hao, Michele C Madigan, Aparajita Khatri, Carl A Power, Tzong-Tyng Hung, Julia Beretov, Lei Chang, Weiwei Xiao, Paul J Cozzi, Peter H Graham, John H Kearsley, Yong Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3411712?pdf=render