Transcriptionally active regions are the preferred targets for chromosomal HPV integration in cervical carcinogenesis.

Integration of human papillomavirus (HPV) into the host genome is regarded as a determining event in cervical carcinogenesis. However, the exact mechanism for integration, and the role of integration in stimulating cancer progression, is not fully characterized. Although integration sites are report...

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Bibliographic Details
Main Authors: Irene Kraus Christiansen, Geir Kjetil Sandve, Martina Schmitz, Matthias Dürst, Eivind Hovig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368827?pdf=render