A novel vector for transgenesis in the rat CNS

A novel vector for transgenesis in the rat CNS

Abstract The larger brain of the rat enables a much greater repertoire of complex behaviors than mice, likely making rats preferential for investigating neurodegeneration. Because molecular tools for specific expression of transgenes in the rat brain are sparse, we chose Prnp encoding the prion prot...

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Bibliographic Details
Main Authors: T. Peter Lopez, Kurt Giles, Brittany N. Dugger, Abby Oehler, Carlo Condello, Zuzana Krejciova, Julian A. Castaneda, George A. Carlson, Stanley B. Prusiner
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Acta Neuropathologica Communications
Subjects:
Scrapie
Vector
Prnp
Neurodegenerative disease
Online Access:http://link.springer.com/article/10.1186/s40478-017-0484-y

Internet

http://link.springer.com/article/10.1186/s40478-017-0484-y

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