18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress

18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress

In cognitively normal patients, mild hyperglycemia selectively decreases 18F-Fluorodeoxyglucose (FDG) uptake in the posterior brain, reproducing Alzheimer disease pattern, hampering the diagnostic accuracy of this widely used tool. This phenomenon might involve either a heterogeneous response of glu...

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Bibliographic Details
Main Authors: Alberto Miceli, Vanessa Cossu, Cecilia Marini, Patrizia Castellani, Stefano Raffa, Maria Isabella Donegani, Silvia Bruno, Silvia Ravera, Laura Emionite, Anna Maria Orengo, Federica Grillo, Flavio Nobili, Silvia Morbelli, Antonio Uccelli, Gianmario Sambuceti, Matteo Bauckneht
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
brain glucose metabolism
FDG-PET
hyperglycemia
oxidative stress
reticular pentose phosphate pathway
Online Access:https://www.mdpi.com/1422-0067/21/21/8154

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https://www.mdpi.com/1422-0067/21/21/8154

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