mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion.

The group I metabotropic glutamate receptor 5 (mGluR5) has been implicated in the pathology of various neurological disorders including schizophrenia, ADHD, and autism. mGluR5-dependent synaptic plasticity has been described at a variety of neural connections and its signaling has been implicated in...

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Bibliographic Details
Main Authors: Chris P Jew, Chia-Shan Wu, Hao Sun, Jie Zhu, Jui-Yen Huang, Dinghui Yu, Nicholas J Justice, Hui-Chen Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3734292?pdf=render