Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

Summary: Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclear. Both WT and mutant proteins undergo extracellular...

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Bibliographic Details
Main Authors: Hao Huang, Alexander Gont, Lynn Kee, Ruben Dries, Kathrin Pfeifer, Bandana Sharma, David N. Debruyne, Matthew Harlow, Satyaki Sengupta, Jikui Guan, Caleb M. Yeung, Wenchao Wang, Bengt Hallberg, Ruth H. Palmer, Meredith S. Irwin, Rani E. George
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
ALK
receptor tyrosine kinase
neuroblastoma
cleavage
MMP-9
migration
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007610

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http://www.sciencedirect.com/science/article/pii/S2211124721007610

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