Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D<sub>2</sub> Derivatives Modified at the Side Chain and the A-Ring

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D<sub>2</sub> Derivatives Modified at the Side Chain and the A-Ring

Experimental data indicate that low-calcemic vitamin D derivatives (VDDs) exhibit anticancer properties, both <i>in vitro</i> and <i>in vivo</i>. In our search for a vitamin D analog as potential anticancer agent, we investigated the influence of chirality in the side chain o...

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Bibliographic Details
Main Authors: Magdalena Milczarek, Michał Chodyński, Anita Pietraszek, Martyna Stachowicz-Suhs, Kaori Yasuda, Toshiyuki Sakaki, Joanna Wietrzyk, Andrzej Kutner
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
vitamin d derivatives
double-point modified vitamin d<sub>2</sub> analogs
1,25-dihydroxyergocalciferol analogs
cyp24a1-dependent metabolism
antiproliferative activity <i>in vitro</i>
human colorectal cancer cell lines
Online Access:https://www.mdpi.com/1422-0067/21/2/642

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https://www.mdpi.com/1422-0067/21/2/642

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