Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of Mycobacterium tuberculosis (Mtb) transpeptidases by carbapenems active against replicating Mtb. Here, we inve...

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Bibliographic Details
Main Authors: Landys Lopez Quezada, Robert Smith, Tania J. Lupoli, Zainab Edoo, Xiaojun Li, Ben Gold, Julia Roberts, Yan Ling, Sae Woong Park, Quyen Nguyen, Frank J. Schoenen, Kelin Li, Jean-Emmanuel Hugonnet, Michel Arthur, James C. Sacchettini, Carl Nathan, Jeffrey Aubé
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
M. tuberculosis
cephalosporin
non-replicating
β-lactams
ABPP
click chemistry
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01248/full

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https://www.frontiersin.org/article/10.3389/fmicb.2020.01248/full

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