PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.

PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.

BACKGROUND: PI3Kgamma functions in the immune compartment to promote inflammation in response to G-protein-coupled receptor (GPCR) agonists and PI3Kgamma also acts within the heart itself both as a negative regulator of cardiac contractility and as a pro-survival factor. Thus, PI3Kgamma has the pote...

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Bibliographic Details
Main Authors: Bernhard J Haubner, G Gregory Neely, Jakob G J Voelkl, Federico Damilano, Keiji Kuba, Yumiko Imai, Vukoslav Komnenovic, Agnes Mayr, Otmar Pachinger, Emilio Hirsch, Josef M Penninger, Bernhard Metzler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2825255?pdf=render

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http://europepmc.org/articles/PMC2825255?pdf=render

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