Expression of dominant-negative thyroid hormone receptor alpha1 in Leydig and Sertoli cells demonstrates no additional defect compared with expression in Sertoli cells only.

Expression of dominant-negative thyroid hormone receptor alpha1 in Leydig and Sertoli cells demonstrates no additional defect compared with expression in Sertoli cells only.

<h4>Background</h4>In the testis, thyroid hormone (T3) regulates the number of gametes produced through its action on Sertoli cell proliferation. However, the role of T3 in the regulation of steroidogenesis is still controversial.<h4>Methods</h4>The TRαAMI knock-in allele all...

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Bibliographic Details
Main Authors: Betty Fumel, Pascal Froment, Martin Holzenberger, Gabriel Livera, Philippe Monget, Sophie Fouchécourt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119392

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https://doi.org/10.1371/journal.pone.0119392

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