Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA

Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA

Abstract Background One problem that plagues epigenome-wide association studies is the potential confounding due to cell mixtures when purified target cells are not available. Reference-free adjustment of cell mixtures has become increasingly popular due to its flexibility and simplicity. However, e...

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Bibliographic Details
Main Authors: Jun Chen, Ehsan Behnam, Jinyan Huang, Miriam F. Moffatt, Daniel J. Schaid, Liming Liang, Xihong Lin
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Genomics
Subjects:
Epigenome-wide association
cell mixture
surrogate variable analysis
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s12864-017-3808-1

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http://link.springer.com/article/10.1186/s12864-017-3808-1

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