TMEM16A Ca2+-activated Cl− channel inhibition ameliorates acute pancreatitis via the IP3R/Ca2+/NFκB/IL-6 signaling pathway

TMEM16A Ca2+-activated Cl− channel inhibition ameliorates acute pancreatitis via the IP3R/Ca2+/NFκB/IL-6 signaling pathway

TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown. Here, we found that increased TMEM16A expression in the pancreatic tissue was...

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Bibliographic Details
Main Authors: Qinghua Wang, Lichuan Bai, Shuya Luo, Tianyu Wang, Fan Yang, Jialin Xia, Hui Wang, Ke Ma, Mei Liu, Shuwei Wu, Huijie Wang, Shibin Guo, Xiaohong Sun, Qinghuan Xiao
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Journal of Advanced Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220300060

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http://www.sciencedirect.com/science/article/pii/S2090123220300060

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