Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

PurposeThe retinal pigment epithelium (RPE) is a main target for complement activation in age-related macular degeneration (AMD). The anaphylatoxins C3a and C5a have been thought to mostly play a role as chemoattractants for macrophages and immune cells; here, we explore whether they trigger RPE alt...

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Bibliographic Details
Main Authors: Catharina Busch, Balasubramaniam Annamalai, Khava Abdusalamova, Nadine Reichhart, Christian Huber, Yuchen Lin, Emeraldo A. H. Jo, Peter F. Zipfel, Christine Skerka, Gerhild Wildner, Maria Diedrichs-Möhring, Bärbel Rohrer, Olaf Strauß
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
anaphylatoxins
calcium signaling
FOXO1
FoxP3
retinal pigment epithelium
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00703/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00703/full

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