Mutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanisms.

Mutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanisms.

The type III receptor tyrosine kinase (RTK) KIT plays a crucial role in the transmission of cellular signals through phosphorylation events that are associated with a switching of the protein conformation between inactive and active states. D816V KIT mutation is associated with various pathologies i...

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Bibliographic Details
Main Authors: Elodie Laine, Isaure Chauvot de Beauchêne, David Perahia, Christian Auclair, Luba Tchertanov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3116893?pdf=render

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http://europepmc.org/articles/PMC3116893?pdf=render

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