Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with <i>MTHFR</i> Methylation Levels

Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with <i>MTHFR</i> Methylation Levels

Methylenetetrahydrofolate reductase (MTHFR) is a pivotal enzyme in the one-carbon metabolism, a metabolic pathway required for DNA synthesis and methylation reactions. <i>MTHFR</i> hypermethylation, resulting in reduced gene expression, can contribute to several human disorders, but litt...

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Bibliographic Details
Main Authors: Fabio Coppedè, Andrea Stoccoro, Pierpaola Tannorella, Roberta Gallo, Vanessa Nicolì, Lucia Migliore
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
methylenetetrahydrofolate reductase
MTHFR
methylation
one-carbon metabolism
folate metabolism
polymorphisms
DNMT3B
epigenetics
Online Access:https://www.mdpi.com/1422-0067/20/15/3754

Internet

https://www.mdpi.com/1422-0067/20/15/3754

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