Augmenting autophagy to treat acute kidney injury during endotoxemia in mice.

Augmenting autophagy to treat acute kidney injury during endotoxemia in mice.

To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic utility in facilitating renal recovery in aged mi...

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Bibliographic Details
Main Authors: Gina M Howell, Hernando Gomez, Richard D Collage, Patricia Loughran, Xianghong Zhang, Daniel A Escobar, Timothy R Billiar, Brian S Zuckerbraun, Matthew R Rosengart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3728340?pdf=render

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http://europepmc.org/articles/PMC3728340?pdf=render

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