Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis

Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis

Abstract Background It is unclear to what extent pre-clinical studies in genetically homogeneous animal models of amyotrophic lateral sclerosis (ALS), an invariably fatal neurodegenerative disorder, can be informative of human pathology. The disease modifying effects in animal models of most therape...

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Main Authors: Irene Zubiri, Vittoria Lombardi, Michael Bremang, Vikram Mitra, Giovanni Nardo, Rocco Adiutori, Ching-Hua Lu, Emanuela Leoni, Ping Yip, Ozlem Yildiz, Malcolm Ward, Linda Greensmith, Caterina Bendotti, Ian Pike, Andrea Malaspina
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
Proteomics
Biomarkers
TMTcalibrator™
SOD1G93A animal models
Online Access:http://link.springer.com/article/10.1186/s13024-018-0292-2

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http://link.springer.com/article/10.1186/s13024-018-0292-2

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