Molecular characterization of an MLL1 fusion and its role in chromosomal instability

Molecular characterization of an MLL1 fusion and its role in chromosomal instability

Chromosomal rearrangements involving the mixed‐lineage leukemia (MLL1) gene are common in a unique group of acute leukemias, with more than 100 fusion partners in this malignancy alone. However, do these fusions occur or have a role in solid tumors? We performed extensive network analyses of MLL1‐fu...

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Bibliographic Details
Main Authors: Sreejit Parameswaran, Frederick S. Vizeacoumar, Kalpana Kalyanasundaram Bhanumathy, Fujun Qin, Md. Fahmid Islam, Behzad M. Toosi, Chelsea E. Cunningham, Darrell D. Mousseau, Maruti C. Uppalapati, Peter C. Stirling, Yuliang Wu, Keith Bonham, Andrew Freywald, Hui Li, Franco J. Vizeacoumar
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Molecular Oncology
Subjects:
chromosomal instability
chromosomal rearrangement
fusion proteins
mitotic checkpoint
tumor heterogeneity
Online Access:https://doi.org/10.1002/1878-0261.12423

Internet

https://doi.org/10.1002/1878-0261.12423

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