Case-crossover and case-time-control studies: concepts, design, and analysis
Background & Aim: Case-crossover studies are the case-control version of crossover studies. In these studies, cases and controls are the same subjects. The term crossover is applied for designs that all subjects pass through both treatment (exposure) and placebo (non-exposure) phases. In fact t...
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Tehran University of Medical Sciences
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doaj-4d81b1ec1cf3454b9878fda9889f5c552020-12-06T04:10:33ZengTehran University of Medical SciencesJournal of Biostatistics and Epidemiology2383-41962383-420X2015-10-0111/2Case-crossover and case-time-control studies: concepts, design, and analysisSeyed Saeed Hashemi-Nazari0Mohammad Ali Mansournia1Safety Promotion and Injury Prevention Research Center AND Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Background & Aim: Case-crossover studies are the case-control version of crossover studies. In these studies, cases and controls are the same subjects. The term crossover is applied for designs that all subjects pass through both treatment (exposure) and placebo (non-exposure) phases. In fact they are crossover of subjects between periods of exposure and non-exposure. This design is most suitable for outcomes, which their induction time is short. Whatever the onset of outcome is more abrupt, it is more amenable to be studied in case-crossover studies. Case-crossover design can be implemented in a number of ways. In this article some common terms in the literature of casecrossover studies, major concerns in selection of controls, different ways for designing casecrossover studies, some examples for analyzing these data according to different sampling designs and also design and analysis of case-time-control designs with practical examples are being explored. https://jbe.tums.ac.ir/index.php/jbe/article/view/16case-crossovercase-time-controldesign and analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seyed Saeed Hashemi-Nazari Mohammad Ali Mansournia |
spellingShingle |
Seyed Saeed Hashemi-Nazari Mohammad Ali Mansournia Case-crossover and case-time-control studies: concepts, design, and analysis Journal of Biostatistics and Epidemiology case-crossover case-time-control design and analysis |
author_facet |
Seyed Saeed Hashemi-Nazari Mohammad Ali Mansournia |
author_sort |
Seyed Saeed Hashemi-Nazari |
title |
Case-crossover and case-time-control studies: concepts, design, and analysis |
title_short |
Case-crossover and case-time-control studies: concepts, design, and analysis |
title_full |
Case-crossover and case-time-control studies: concepts, design, and analysis |
title_fullStr |
Case-crossover and case-time-control studies: concepts, design, and analysis |
title_full_unstemmed |
Case-crossover and case-time-control studies: concepts, design, and analysis |
title_sort |
case-crossover and case-time-control studies: concepts, design, and analysis |
publisher |
Tehran University of Medical Sciences |
series |
Journal of Biostatistics and Epidemiology |
issn |
2383-4196 2383-420X |
publishDate |
2015-10-01 |
description |
Background & Aim: Case-crossover studies are the case-control version of crossover studies. In these studies, cases and controls are the same subjects. The term crossover is applied for designs that all subjects pass through both treatment (exposure) and placebo (non-exposure) phases. In fact they are crossover of subjects between periods of exposure and non-exposure. This design is most suitable for outcomes, which their induction time is short. Whatever the onset of outcome is more abrupt, it is more amenable to be studied in case-crossover studies. Case-crossover design can be implemented in a number of ways. In this article some common terms in the literature of casecrossover studies, major concerns in selection of controls, different ways for designing casecrossover studies, some examples for analyzing these data according to different sampling designs and also design and analysis of case-time-control designs with practical examples are being explored.
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topic |
case-crossover case-time-control design and analysis |
url |
https://jbe.tums.ac.ir/index.php/jbe/article/view/16 |
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AT seyedsaeedhasheminazari casecrossoverandcasetimecontrolstudiesconceptsdesignandanalysis AT mohammadalimansournia casecrossoverandcasetimecontrolstudiesconceptsdesignandanalysis |
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