Co-Application of Eugenol and QX-314 Elicits the Prolonged Blockade of Voltage-Gated Sodium Channels in Nociceptive Trigeminal Ganglion Neurons

Co-Application of Eugenol and QX-314 Elicits the Prolonged Blockade of Voltage-Gated Sodium Channels in Nociceptive Trigeminal Ganglion Neurons

Local anesthetics (LAs) can completely block nociception by inhibiting voltage-gated sodium channels (VGSCs), and thus, blocking action potentials (APs) within sensory neurons. As one of the several LAs, eugenol is used for dental pain treatment. It reportedly features multiple functions in regulati...

Full description

Bibliographic Details
Main Authors: Sung-Min Hwang, Kihwan Lee, Sang-Taek Im, Eun Jin Go, Yong Ho Kim, Chul-Kyu Park
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomolecules
Subjects:
local anesthetic
eugenol
QX-314
voltage-gated sodium channels
TRPV1
nociception
Online Access:https://www.mdpi.com/2218-273X/10/11/1513

Internet

https://www.mdpi.com/2218-273X/10/11/1513

Similar Items