Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology

Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology

The effect of copper on the mitochondrial carnitine/acylcarnitine carrier (CAC) was studied. Transport function was assayed as [<sup>3</sup>H]carnitine/carnitine antiport in proteoliposomes reconstituted with the native protein extracted from rat liver mitochondria or with the recombinan...

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Bibliographic Details
Main Authors: Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mario Prejanò, Tiziana Marino, Nino Russo, Cesare Indiveri
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
carnitine
copper
membrane transport
toxicology
computational chemistry
Online Access:https://www.mdpi.com/1420-3049/25/4/820

Internet

https://www.mdpi.com/1420-3049/25/4/820

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