Role of C5aR1 and C5L2 Receptors in Ischemia-Reperfusion Injury

Role of C5aR1 and C5L2 Receptors in Ischemia-Reperfusion Injury

The role of C5a receptors (C5aR1 and C5L2) in renal ischemia-reperfusion injury (IRI) is uncertain. We generated an in vitro model of hypoxia/reoxygenation with human proximal tubule epithelial cells to mimic some IRI events. C5aR1, membrane attack complex (MAC) and factor H (FH) deposits were evalu...

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Bibliographic Details
Main Authors: Carlos Arias-Cabrales, Eva Rodriguez-Garcia, Javier Gimeno, David Benito, María José Pérez-Sáez, Dolores Redondo-Pachón, Anna Buxeda, Carla Burballa, Marta Crespo, Marta Riera, Julio Pascual
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Journal of Clinical Medicine
Subjects:
kidney transplant
ischemia-reperfusion injury
delayed graft function
complement system
C5a receptors
Online Access:https://www.mdpi.com/2077-0383/10/5/974

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https://www.mdpi.com/2077-0383/10/5/974

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