Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A

Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A

In an effort to find potent inhibitors of the protein kinases DYRK1A and CDK1/Cyclin B, a systematic in vitro evaluation of 2,500 plant extracts from New Caledonia and French Guyana was performed. Some extracts were found to strongly inhibit the activity of these kinases. Four aristolactams and one...

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Bibliographic Details
Main Authors: Françoise Guéritte, Marc Litaudon, Laurent Meijer, Olivier Lozach, Vincent Dumontet, Séverine Amand, Bernard Bodo, Cécile Apel, Jessica Le Ven, Véronique Eparvier, Barbara Morleo, Guillaume Marti
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
Oxandra asbeckii
Goniothalamus dumontetii
Siparuna spp.
aporphinoids and aristolactams
kinases inhibitors
Online Access:http://www.mdpi.com/1420-3049/18/3/3018

Internet

http://www.mdpi.com/1420-3049/18/3/3018

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