Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly

Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly

Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises ~1 in 250 conceptions. It is associated with predisposing mutations in the Nodal and Hedgehog (HH) pathways, with penetrance and expressivity graded by genetic and environmental modifiers, via poorly underst...

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Bibliographic Details
Main Authors: Mingi Hong, Annabel Christ, Anna Christa, Thomas E Willnow, Robert S Krauss
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
holoprosencephaly
fetal alcohol
birth defect
Nodal signaling
hedgehog signaling
gene-environment interaction
Online Access:https://elifesciences.org/articles/60351

Internet

https://elifesciences.org/articles/60351

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