Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells

Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells

Summary: The effects of ascorbate on adult cell fate specification remain largely unknown. Using our stepwise and chemically defined system to derive lateral mesoderm progenitors from human pluripotent stem cells (hPSCs), we found that ascorbate increased the expression of mesenchymal stromal cell (...

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Bibliographic Details
Main Authors: Tong Ming Liu, Ege Deniz Yildirim, Pin Li, Hai Tong Fang, Vinitha Denslin, Vibhor Kumar, Yuin Han Loh, Eng Hin Lee, Simon M. Cool, Bin Tean Teh, James H. Hui, Bing Lim, Ng Shyh-Chang
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671120300023

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http://www.sciencedirect.com/science/article/pii/S2213671120300023

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