HDAC1-mediated deacetylation of HIF1α prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2

HDAC1-mediated deacetylation of HIF1α prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2

We intended to characterize functional relevance of microRNA (miR)-224-3p in endothelial cell (EC) apoptosis and reactive oxygen species (ROS) accumulation in atherosclerosis, considering also the integral involvement of histone deacetylase 1 (HDAC1)-mediated hypoxia-inducible factor-1α (HIF1α) deac...

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Bibliographic Details
Main Authors: Hao Wang, Kazuo Sugimoto, Hao Lu, Wan-Yong Yang, Ji-Yue Liu, Hong-Yu Yang, Yue-Bo Song, Dong Yan, Tian-Yu Zou, Si Shen
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
HDAC1
HIF1α
miR-224-3p
FOSL2
atherosclerosis
endothelial cell apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303565

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http://www.sciencedirect.com/science/article/pii/S2162253120303565

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