Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma

Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma

Dysregulated amino acids metabolism reciprocally interplays with evolutionary phenotypic characteristics of cancer cells to enhance metastasis. The high metastasis potential of oral squamous cell carcinoma (OSCC) can manifest with perineural invasion (PNI). We here aimed to determine the role of ami...

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Bibliographic Details
Main Authors: Yong Fu, Liang Ding, Xihu Yang, Zhuang Ding, Xiaofeng Huang, Lei Zhang, Sheng Chen, Qingang Hu, Yanhong Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
amino acids metabolism
asparagine synthetase (ASNS)
l-asparagine
perineural invasion (PNI)
oral squamous cell carcinoma (OSCC)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.637226/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.637226/full

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