Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway

Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway

Background: Tumor compression-induced pain (TCIP) is a complex pathological cancer pain. Spinal glial cells play a critical role in maintenance of cancer pain by releasing proinflammatory cytokines and chemokines. In this study, we verified the role of levo-corydalmine (l-CDL) on TCIP. Methods: Spon...

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Bibliographic Details
Main Authors: Yahui Hu, Nandani Darshika Kodithuwakku, Lin Zhou, Chengyuan Li, Dan Han, Weirong Fang, Jihua Liu, Yunman Li
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
microglia
astrocytes
tumor compression-induced pain (TCIP)
CCL2
CCR2
inflammatory cytokines
levo-corydalmine (l-CDL)
Online Access:http://www.mdpi.com/1420-3049/22/6/937

Internet

http://www.mdpi.com/1420-3049/22/6/937

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