RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice

RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice

RIPK3 mediates cell death and regulates inflammatory responses. Although genetic studies have suggested that RIPK3-MLKL-mediated necroptosis leads to embryonic lethality in Fadd or Caspase-8-deficient mice, the exact mechanisms are not fully understood. Here, we generated Ripk3 mutant mice by alteri...

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Bibliographic Details
Main Authors: Qun Zhao, XianJun Yu, HaiWei Zhang, YongBo Liu, XiXi Zhang, XiaoXia Wu, Qun Xie, Ming Li, Hao Ying, Haibing Zhang
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
RIPK3
Fadd
kinase activity
necroptosis
embryogenesis
inflammation
cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304862

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http://www.sciencedirect.com/science/article/pii/S2211124717304862

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