TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells

TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells

Amyotrophic Lateral Sclerosis (ALS) is characterized by degeneration of motor neurons in the brain and spinal cord. Cytoplasmic inclusions of TDP-43 are frequently reported in motor neurons of ALS patients. TDP-43 has also been shown to associate with stress granules (SGs), a complex of proteins and...

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Bibliographic Details
Main Authors: Qiao Ding, Justin Chaplin, Matthew J. Morris, Massimo A. Hilliard, Ernst Wolvetang, Dominic C. H. Ng, Peter G. Noakes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TDP-43
stress granules
translation
motor neurons
cytoplasmic inclusions
amyotrophic lateral sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.611601/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.611601/full

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