TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells
Amyotrophic Lateral Sclerosis (ALS) is characterized by degeneration of motor neurons in the brain and spinal cord. Cytoplasmic inclusions of TDP-43 are frequently reported in motor neurons of ALS patients. TDP-43 has also been shown to associate with stress granules (SGs), a complex of proteins and...
Main Authors: | Qiao Ding, Justin Chaplin, Matthew J. Morris, Massimo A. Hilliard, Ernst Wolvetang, Dominic C. H. Ng, Peter G. Noakes |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-06-01
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Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.611601/full |
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