KIR, HLA, and IL28B variant predict response to antiviral therapy in genotype 1 chronic hepatitis C patients in Japan.

KIR, HLA, and IL28B variant predict response to antiviral therapy in genotype 1 chronic hepatitis C patients in Japan.

Natural killer cell responses play a crucial role in virus clearance by the innate immune system. Although the killer immunoglobulin-like receptor (KIR) in combination with its cognate human leukocyte antigen (HLA) ligand, especially KIR2DL3-HLA-C1, is associated with both treatment-induced and spon...

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Main Authors: Yuichi Nozawa, Takeji Umemura, Satoru Joshita, Yoshihiko Katsuyama, Soichiro Shibata, Takefumi Kimura, Susumu Morita, Michiharu Komatsu, Akihiro Matsumoto, Eiji Tanaka, Masao Ota
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3861489?pdf=render

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http://europepmc.org/articles/PMC3861489?pdf=render

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