Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function

Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function

Summary: Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atypical protein kinase Cs (aPKCs). A planar cell pol...

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Bibliographic Details
Main Authors: John Scott, Sonal Thakar, Ye Mao, Huaping Qin, Helen Hejran, Su-Yee Lee, Ting Yu, Olga Klezovitch, Hongqiang Cheng, Yongxin Mu, Sourav Ghosh, Valeri Vasioukhin, Yimin Zou
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219303426

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http://www.sciencedirect.com/science/article/pii/S2589004219303426

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