Split-CreERT2: temporal control of DNA recombination mediated by split-Cre protein fragment complementation.

BACKGROUND:DNA recombination technologies such as the Cre/LoxP system advance modern biological research by allowing conditional gene regulation in vivo. However, the precise targeting of a particular cell type at a given time point has remained challenging since spatial specificity has so far depen...

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Bibliographic Details
Main Authors: Johannes Hirrlinger, Robert P Requardt, Ulrike Winkler, Franziska Wilhelm, Christine Schulze, Petra G Hirrlinger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2791205?pdf=render