Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded Nicotinamide Pellets Using a Quality by Design Approach

Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded Nicotinamide Pellets Using a Quality by Design Approach

The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of t...

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Bibliographic Details
Main Authors: Eva-Maria Theismann, Julia K. Keppler, Martin Owen, Karin Schwarz, Walkiria Schlindwein
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Pharmaceutics
Subjects:
wet extrusion-spheronisation
quality by design
design of experiment (DoE)
niacin
controlled release
Online Access:https://www.mdpi.com/1999-4923/11/4/154

Internet

https://www.mdpi.com/1999-4923/11/4/154

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