Effect of Polymers and Storage Relative Humidity on Amorphous Rebamipide and Its Solid Dispersion Transformation: Multiple Spectra Chemometrics of Powder X-Ray Diffraction and Near-Infrared Spectroscopy

Effect of Polymers and Storage Relative Humidity on Amorphous Rebamipide and Its Solid Dispersion Transformation: Multiple Spectra Chemometrics of Powder X-Ray Diffraction and Near-Infrared Spectroscopy

This study aimed to investigate the effect of polymers and storage relative humidity on amorphous rebamipide (RB) and its solid dispersion phase transformation using chemometrics based on multiple datasets. The amorphous RB was prepared using particle mixture and grinding methods with hydroxypropyl...

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Bibliographic Details
Main Authors: Yuta Otsuka, Yuiko Utsunomiya, Daiki Umeda, Etsuo Yonemochi, Yayoi Kawano, Takehisa Hanawa
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceuticals
Subjects:
rebamipide
X-ray diffraction
near-infrared spectroscopy
principal component analysis
Online Access:https://www.mdpi.com/1424-8247/13/7/147

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https://www.mdpi.com/1424-8247/13/7/147

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