Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia

Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia

Abstract Ubiquilin-2 (UBQLN2) is a member of the ubiquilin family, actively implicated in the degradation of misfolded and redundant proteins through the ubiquitin-proteasome system and macroautophagy. UBQLN2 received much attention after the discovery of gene mutations in amyotrophic lateral sclero...

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Bibliographic Details
Main Authors: Laurence Renaud, Vincent Picher-Martel, Philippe Codron, Jean-Pierre Julien
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis (ALS)
Ubiquilin-2 (UBQLN2)
TAR DNA-binding protein 43 (TDP-43)
Ubiquitin-proteasome system (UPS)
Autophagy
Animal models
Online Access:http://link.springer.com/article/10.1186/s40478-019-0758-7

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http://link.springer.com/article/10.1186/s40478-019-0758-7

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