Histone Deacetylase 4 Promotes Osteosarcoma Cell Proliferation and Invasion by Regulating Expression of Proliferating Cell Nuclear Antigen

Histone Deacetylase 4 Promotes Osteosarcoma Cell Proliferation and Invasion by Regulating Expression of Proliferating Cell Nuclear Antigen

Background/Aims: Osteosarcoma (OS) is commonly characterized by lower survival rates and high incidences of local recurrence due to its highly aggressive nature and metastatic tendencies. Studies have shown that histone deacetylase 4 (HDAC4) and proliferating cell nuclear antigen (PCNA) are highly e...

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Bibliographic Details
Main Authors: Kun Cao, Hao Wang, Yueyang Fang, Yuan Wang, Lei Wei, Xi Chen, Zheng Jiang, Xiaochun Wei, Yong Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
HDAC4
PCNA
ubiquitination
progression
osteosarcoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00870/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00870/full

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