The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating actin polymerization, but through c-Abl survival...

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Bibliographic Details
Main Authors: Lijian Shao, Jianhui Chang, Wei Feng, Xiaoyan Wang, Elizabeth A. Williamson, Ying Li, Amir Schajnovitz, David Scadden, Luke J. Mortensen, Charles P. Lin, Linheng Li, Ariel Paulson, James Downing, Daohong Zhou, Robert A. Hromas
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04716-5

Internet

https://doi.org/10.1038/s41467-018-04716-5

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